Caiaphas intended his words in a very different sense than the true testimony they gave of the saving work of God through Jesus Christ. He meant to justify the murder of an innocent man as a political expediency. Yet it was God's purpose that the High Priest's office should be one of His witnesses, and so it came to pass, even without the willing cooperation of Caiaphas. His words said more than he knew.
At a later occasion, when the crowds loudly heralded Jesus' entry into Jerusalem as their king, the Pharisees protested that testimony. But Jesus answered them, "I tell you that, if these should hold their peace, the stones would immediately cry out" (Luke 19:40b). Nothing could stop the witness program of God with respect to His Only Begotten Son, Jesus Christ. And God has made His witnesses powerful and compelling in the precincts of our individual hearts by the confirming ministry of His Holy Spirit.
Each of our hearts is like a little judgment bar that must consider the evidence and pass a verdict. However, the judgment will not determine His sentence, but our own. If we reject God's compelling testimony concerning His Son for any of the countless reasons that spring up in the sinful heart of man, we cut ourselves off from the only way of salvation from sin - in this world or the next.
It is difficult for human hearts to accept the testimony of God's Word, for in doing so we condemn ourselves. But in God's grace, those who do acknowledge their sin are the ones that receive his forgiveness. The Bible witnesses both of our fallen sinful condition and of God's loving Saviour who died for our sins. Those who honestly receive that testimony by faith become God's dear children.